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embitter
(archaic) To cause (something) to be or taste bitter; to bitter.
(figurative)
To cause (a positive quality such as happiness, or a thing such as an activity or one's life) to become less good or pleasurable; also, to make (a negative quality, or thing such as a disagreement) worse or more unpleasant.
To cause (someone or their feelings) to become more angry, resentful, or unfriendly; to envenom.